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Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis

Mié, 14/03/2018 - 18:21
AbstractObjectiveTo evaluate rates of serious organ specific immune-related adverse events, general adverse events related to immune activation, and adverse events consistent with musculoskeletal...

Global watchdog to counter big tobacco

Mié, 14/03/2018 - 17:36
The US philanthropist Michael Bloomberg will spend $20m (£14m; €16m) to launch a global watchdog to monitor and expose nefarious tobacco industry activities. This comes amid growing complaints about...

Beyond behaviour: changing foods as well as changing people

Mié, 14/03/2018 - 17:21
Like many specialists in public health, Clarke focuses on “ways to change and sustain our individual behaviour.”1For dietary problems, this has meant 30 years of trying to get people all over the...

BMA is “deeply concerned” by 35% rise in spending on private providers in three years

Mié, 14/03/2018 - 11:51
Spending on independent sector providers (ISPs) for NHS services by the Department of Health has risen by £2.5bn (€2.8bn; $3.5bn) over three years to £9bn, an analysis by the BMA has found.1The BMA...

Margaret McCartney: Cancer patients should not be shamed

Lun, 12/03/2018 - 19:26
The charity Cancer Research UK has gone large on its publicity campaign about obesity. Bus stops and advertising hoardings are replete with black text on a white background. The adverts invite us to...

Quebec doctors reject pay rise in favour of investment in health system

Lun, 12/03/2018 - 18:51
Hundreds of doctors in Quebec are turning down pay rises, saying that they are too embarrassed to accept the higher payments while colleagues and patients are struggling in a health system beset by...

GP leaders pass vote of no confidence in GMC

Lun, 12/03/2018 - 13:51
General practice leaders have passed a vote of no confidence in the General Medical Council (GMC) in light of the regulator’s actions in the Hadiza Bawa-Garba case.A motion passed at the annual UK...

Predicted rise in trusts’ income from private patients fails to materialise

Lun, 12/03/2018 - 12:46
Private patients remain a very small proportion of all patients treated by NHS hospitals, in spite of legislation in 2012 that opened the door to increased private income.Critics of Andrew Lansley’s...

US opioid overdoses rise by 30% in one year

Lun, 12/03/2018 - 10:56
An increased government focus on the US opioid crisis has not yet slowed the epidemic’s growth, according to new data from the Centers for Disease Control (CDC).Emergency department visits for...

NHS should reȷect online GP schemes that “cherry pick” patients, say LMCs

Vie, 09/03/2018 - 17:21
Services that allow patients to consult online with their GP should not be established in the NHS unless they are willing to provide comprehensive care to all patients, general practice leaders have...

Effectiveness of antidepressants

Vie, 09/03/2018 - 16:26
A recent meta-analysis by Cipriani and colleagues provides as good and balanced a synopsis as we will likely ever have of the results from the 522 trials of 21 antidepressants in 116 477...

Government must introduce incentives to retain older GPs, says BMA

Vie, 09/03/2018 - 16:25
GPs have called on the government to invest in an incentive scheme to encourage GPs into permanent roles and look at ways to retain older GPs, the BMA has said.Delegates at the BMA’s annual UK...

How can the NHS become a millennial friendly employer?

Vie, 09/03/2018 - 16:25
The panelFiona Godlee, editor in chief, The BMJ (chair)Candace Imison, director of policy, Nuffield TrustBob Klaber, consultant paediatrician and associate medical director, Imperial College...

Parts of new Scottish GP contract could benefit English colleagues, say GPs

Vie, 09/03/2018 - 15:51
The GP contract in England should incorporate elements of the new Scottish GP contract, members of the profession have said.In January GPs in Scotland voted by a large majority to accept a new...

Endovascular treatment for acute ischaemic stroke in routine clinical practice: prospective, observational cohort study (MR CLEAN Registry)

Vie, 09/03/2018 - 15:16
AbstractObjectiveTo determine outcomes and safety of endovascular treatment for acute ischaemic stroke, due to proximal intracranial vessel occlusion in the anterior circulation, in routine clinical...

Pop a million happy pills? Antidepressants, nuance, and the media

Vie, 09/03/2018 - 14:31
“Pop more happy pills,” screamed the Sun’s front page on 22 February. It referred to the first major network meta-analysis comparing 21 antidepressants for acute depression in adults, published in...

Plans to restrict access to drugs will put vulnerable patients at risk, BMA argues

Jue, 08/03/2018 - 12:16
Proposals to restrict access to drugs that can be bought over the counter for minor, short term conditions will put vulnerable patients at risk, the BMA has warned.NHS England is consulting on plans...

Budget cuts force local councils into “narrow” focus on social care, warns watchdog

Jue, 08/03/2018 - 12:06
Local authorities in England are being forced to prioritise adult social care over other vital services such as housing because of swingeing central budget cuts, the public spending watchdog has...

Barriers for mental health services for children and adolescents are too high, finds regulator

Jue, 08/03/2018 - 11:51
Mental health services for children and adolescents in England are not working well, the Care Quality Commission has said in a new report.Schools, local authorities, and the NHS are not working...

Key design considerations for adaptive clinical trials: a primer for clinicians

Jue, 08/03/2018 - 11:11
Summary pointsAdaptive trials enable continual modification to the trial design based on interim data. They can reduce use of resources and time or improve the likelihood of success of the...

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