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On the Front Lines of the Opioid Epidemic in Huntington, West Virginia

Mar, 10/04/2018 - 02:00
This Medical News article profiles Beth Toppins, an emergency physician on the front lines of the opioid epidemic in Huntington, West Virginia. It is part of an ongoing JAMA News series profiling the daily routine of health care professionals making a difference in their communities.

Did Trehalose Contribute to the C. difficile Epidemic?

Mar, 10/04/2018 - 02:00
This Medical News article discusses whether trehalose, a sugar manufactured from cornstarch used to sweeten and texturize foods, has contributed to the emergence of epidemic strains of Clostridium difficile infection (CDI).

Organoids Help Choose Cancer Drugs

Mar, 10/04/2018 - 02:00
In a first-of-its-kind trial, researchers used tiny, simplified organs grown from patients’ cancer cells—so-called patient-derived organoids (PDOs)—to compare responses to anticancer agents in the laboratory and the clinic. The researchers focused on patients with chemotherapy-resistant metastatic gastrointestinal cancers. For these patients, targeted agents or novel investigational drugs can prolong survival, but in most cases no predictive biomarkers are available, so the process relies on trial and error.

Personal Genomics Meets Cryptocurrency

Mar, 10/04/2018 - 02:00
The newest entry into the field of personal genomics will let consumers sell access to their genomes for tokens that can be exchanged for other cryptocurrencies. The founders of Nebula Genomics—including sequencing pioneer George Church, PhD—announced the new genetic data sharing and analysis platform in a white paper in February.

Improving Cardiogenic Shock Treatment

Mar, 10/04/2018 - 02:00
Data from an already existing heart device could help cardiologists better manage cardiogenic shock, a life-threatening condition in which the organ suddenly can’t pump enough blood.

Lasting Effects of Childhood TBI

Mar, 10/04/2018 - 02:00
Traumatic brain injuries (TBI) during childhood can reduce financial and social well-being into adulthood, according to a recent CDC report prepared for Congress.

Risks of “Raw Water”

Mar, 10/04/2018 - 02:00
People who drink raw water or untreated water being sold in some parts of the country may be at risk of developing waterborne illness, according to an official at the CDC.

Washed Feet

Mar, 10/04/2018 - 02:00
Undergirding layers ofdirtskin, andadiposea scaffold of bone stands, twenty-sixprecise pieces (sans the sesamoids).

Queries and Minor Notes

Mar, 10/04/2018 - 02:00

Queries and Minor Notes

Mar, 10/04/2018 - 02:00

Medications for Asthma

Mar, 10/04/2018 - 02:00
This JAMA Patient Page describes the medications used to treat asthma.

JAMA

Mar, 10/04/2018 - 02:00

Highlights for April 3, 2018

Mar, 03/04/2018 - 02:00

Institutional Research Misconduct Reports Need More Credibility

Mar, 03/04/2018 - 02:00
This Viewpoint highlights the inadequacy and lack of transparency of most research institutions’ responses to allegations of research misconduct, and describes development of a proposed checklist to establish definitions and standards for complete research integrity investigations.

Big Data and Machine Learning in Health Care

Mar, 03/04/2018 - 02:00
This Viewpoint discusses how newer technologies such as machine learning and the compilation of “big data” can be used for research and clinical applications.

Individualizing Blood Pressure Targets for People With Diabetes and Hypertension

Mar, 03/04/2018 - 02:00
This Viewpoint compares and contrasts recommendations from the 2017 ADA and ACC/AHA guidelines for management of high blood pressure and argues for individualization of patient goals and blood pressure targets.

Service Sharing as a Path to Viability for Small Physician Practices

Mar, 03/04/2018 - 02:00
This Viewpoint discusses the use of shared service arrangements as a means for small physician practices to pool and manage resources, stay competitive for value-based contracts, and remain viable in the face of market forces favoring consolidation.

Telehealth in Times of Natural Disaster

Mar, 03/04/2018 - 02:00
In this essay, the author uses her experience helping patients in Houston, Texas, following Hurricane Harvey via a computer screen in an onsight medical facility to demonstrate that telecommunications offers much needed help to patients caught in natural disasters.

Lipid Lowering in Acute Coronary Syndrome

Mar, 03/04/2018 - 02:00
The beneficial effect of lipid lowering with statins in randomized clinical trials has had a profound effect on patient outcomes and informing treatment algorithms for cardiovascular prevention. These studies have increasingly emphasized the importance of the direct relationship between the degree of lipid lowering and clinical benefit, with the greatest effect observed among patients at the highest risk of having a subsequent cardiovascular event. Such observations have informed treatment guidelines, which strongly advocate for use of intensive statin therapy for patients with the highest cardiovascular risk.

Sudden Loss of Wealth and Increased Risk of Death

Mar, 03/04/2018 - 02:00
Whether it is the consequence of unfortunate decisions or unavoidable circumstances, financial loss and ruin can disrupt lives and can be both a result and a harbinger of catastrophic decline in health. The intriguing study by Pool and colleagues in this issue of JAMA raises an important question that has been easier to explore with anecdotes and hypothetical examples than by analyzing population data: is financial ruin a harbinger of physical decline? Specifically, are people who lose much of their wealth more likely to die?

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