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Human Gene Therapy Advances

Mar, 09/01/2018 - 01:00
Researchers recently announced 2 gene therapy advances in humans.

New Device Helps Treat River Blindness

Mar, 09/01/2018 - 01:00
With a new cell phone–based diagnostic tool, health care workers in Cameroon were able to reinstate community-wide drug treatment for onchocerciasis, or river blindness, a disease caused by infection with the parasitic worm Onchocerca volvulus. If left untreated, the infection can lead to irreversible vision loss.

High Cost of Investigating Measles Cases

Mar, 09/01/2018 - 01:00
Two unrelated measles cases in the Denver metropolitan area cost nearly $70?000 to investigate, according to a recent CDC report.

15% of HIV Infections Undiagnosed in 2015

Mar, 09/01/2018 - 01:00
An estimated 14.5% of the 1?122?900 US individuals 13 years of age or older living with HIV in 2015 did not know they were infected, found a recent CDC study that analyzed National HIV Surveillance System data. They account for about 40% of ongoing transmissions of virus in the United States. Across states, the percentage of undiagnosed HIV infections ranged from 5.7% to 18.5%; half of undiagnosed infections were in the South.

One Minute

Mar, 09/01/2018 - 01:00
The maple leaves abscondwith summer's green rainon such little stems connecting to spring's essence, summer twigs' foliage,the company of the living.

Book Notices

Mar, 09/01/2018 - 01:00
Massage: Its Principles and Practice. By James B. Mennell, M.A., M.D., B.C., Medical Officer, Physico-Therapeutic Department, St. Thomas’ Hospital. With an Introduction by Sir Robert Jones, C.B., F.R.C.S., Colonel R. A. M. C., Inspector of Military Orthopedics. Cloth. Price, $3 net. Pp. 359, with 135 illustrations. Philadelphia: P. Blakiston’s Son & Co., 1917.

Screening for Scoliosis in Adolescents

Mar, 09/01/2018 - 01:00
This JAMA Patient Page discusses the US Preventive Services Task Force’s recommendations on screening for adolescent idiopathic scoliosis.


Mar, 09/01/2018 - 01:00

Highlights for January 2, 2017

Mar, 02/01/2018 - 01:00

Is Single-Payer System the Next Answer for US Health Care?

Mar, 02/01/2018 - 01:00
In this Viewpoint, Victor Fuchs discusses the prospects that a single-payer health system can solve the 3 principal problems that bedevil US health care: the uninsured, poor outcomes, and high costs.

Canada as Single-Payer Exemplar for Universal Health Care in the United States

Mar, 02/01/2018 - 01:00
In this Viewpoint, David Naylor reviews the many differences between the United States and Canada that preclude the Canadian single-payer system from being a useful exemplar for US health reform.

Fostering Collaboration Between Clinicians and Computers

Mar, 02/01/2018 - 01:00
In this Viewpoint, Verghese and colleagues discuss the promise and challenges of integrating artificial intelligence (AI) into clinical care and argue that AI will always need guidance by physicians if it is to improve the care of patients.

Pediatric Exclusivity and the Regulatory Authority of the FDA

Mar, 02/01/2018 - 01:00
This Viewpoint uses the legal dispute between Amgen and the US Food and Drug Administration (FDA) regarding the FDA’s denial of market exclusivity for cinacalcet to discuss the FDA policy granting 6 months of market exclusivity as an incentive for manufacturers to conduct efficacy and safety studies in child populations.

Listening for a Patient’s Story

Mar, 02/01/2018 - 01:00
In this essay, the author ponders how his 70-year-old patient’s need to tell his story before talking about his own health care needs reminds him of the necessity of listening to patients to know them enough to provide precise care.

Disparities in Live Donor Kidney Transplantation Related to Poverty, Race, or Ethnicity?

Mar, 02/01/2018 - 01:00
Over the past 2 decades, increasing national and local attention has been placed on promoting increases in live donor kidney transplantation in the United States and in addressing existing racial/ethnic disparities in the rates of live donor transplantation. Still, a large gap exists between current realities and proposed goals.

Effect of Mechanically Expanded vs Self-Expanding TAVR for Aortic Stenosis

Mar, 02/01/2018 - 01:00
This randomized noninferiority trial compares the effect of mechanically expanded vs self-expanding transcatheter aortic valve replacement (TAVR) on mortality and major adverse clinical events in patients with aortic stenosis at high or extreme risk of adverse outcomes.

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes

Mar, 02/01/2018 - 01:00
This randomized clinical trial tested the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of type 1 diabetes in young children.

Trends in Live Donor Kidney Transplantation Receipt by Race/Ethnicity, 1995-2014

Mar, 02/01/2018 - 01:00
This study uses Scientific Registry of Transplant Recipients registry data to compare kidney transplantation rates among white, black, Hispanic, and Asian recipient candidates in 1995-1999 vs 2010-2014.

Sepsis Recovery: Recognition and Management of Long-term Sequelae

Mar, 02/01/2018 - 01:00
This narrative review summarizes the epidemiology and pathophysiology of sepsis, management of post-sepsis sequelae in the months following hospital discharge, and directions for future research to reduce long-term sequelae and improve patient recovery.

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